Hi There,
Yes you can! And I have an article that details how to control your robot from C# here on CodeProject. Have a look here:
Basic Robot Control using NKH Mindsqualls Libraries[
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It uses the NKH Mindsqualls library, you may wish to see if there is a new version. It works really well and my article shows how to do the basics which includes running motors.
Hope this helps,
Ed
Edit: Have a look at this page for a quick start guide to getting working with the library, it has all the essentials:
http://www.mindsqualls.net/QuickStart_2_0.aspx[
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(There is also v2.2 of the library available that I think you may want to download.)